She was trained by her father, as well as her other family members. She went to Nasr school in Hyderabad and later graduated from St. Mary's College.

Sania picked her maiden Grand Slam title in the 2009 Australian Open. Partnered with Mahesh Bhupathi, she won the mixed doubles title beating Nathalie Dechy (France) and Andy Ram (Israel) 6-3, 6-1 in the final in Melbourne.